RX: Pain Gel

Yes, but it's handled for you. When you order, you'll complete a short online health questionnaire. A licensed provider reviews it and issues your prescription. The entire process happens online. No office visit, no separate appointment.

If your provider determines this isn't right for you, you pay nothing. Full refund, no questions asked.

Ibuprofen is an oral NSAID that passes through your entire digestive system. Ketro RX is applied directly to the site of pain. Same class of medication, targeted delivery, no GI side effects.

Much, much stronger. That's the point. OTC Voltaren is 1% diclofenac, the strength allowed on a drugstore shelf. Ketro RX is ketorolac, an NSAID in the same class that's strong enough to require a prescription. Same idea, different league.

Both are NSAIDs applied topically. Diclofenac has been available OTC since 2020 and is widely prescribed for mild-to-moderate joint pain. Ketorolac is used in IV and IM form for post-surgical pain in hospitals, and compounded topically when a stronger NSAID is warranted. Peer-reviewed studies show topical ketorolac outperforms placebo for acute inflammation.

Ketro RX is designed for localized pain where you want prescription-strength relief applied directly to the area instead of taking oral medication. Common use cases include:

TMJ and jaw pain — applied along the jawline and temple area for temporomandibular joint discomfort, jaw clenching, and teeth grinding tension.

Arthritis (knee, hip, hand, wrist) — for osteoarthritis and inflammatory joint pain where oral NSAIDs carry GI risk, especially with long-term daily use.

Neck and upper back pain — desk tension, cervical stiffness, and upper trapezius tightness from long hours at a computer or phone.

Shoulder injuries — rotator cuff strains, frozen shoulder, and overuse injuries from sports or repetitive motion.

Lower back pain — localized lumbar pain, muscle spasms, and post-exertion soreness.

Tennis elbow and golfer's elbow — lateral and medial epicondylitis from racquet sports, golf, weightlifting, or repetitive gripping.

Knee pain — runner's knee, patellofemoral pain, post-surgical recovery, and general knee inflammation.

Plantar fasciitis and foot pain — heel pain, arch inflammation, and Achilles tendon discomfort.

Sports injuries — sprains, strains, and acute muscle injuries from training, competition, or weekend athletics. Originally formulated for professional baseball players.

Tension headaches — applied to the temples, forehead, and base of the skull for headache and migraine-associated tension.

Chronic localized pain — ongoing pain in a specific area where daily oral NSAID use is not advisable due to GI, kidney, or cardiovascular risk.

Post-surgical pain — localized pain management after orthopedic procedures, dental surgery, or other surgical recovery where targeted relief is preferred.

Carpal tunnel and wrist pain — repetitive strain from typing, gaming, or manual work.

Hip pain — bursitis, labral discomfort, and hip flexor tightness.

Fibromyalgia — localized flare-ups, tender points, and widespread musculoskeletal pain. Topical application allows you to target specific flare areas without adding another oral medication to your regimen.

Ehlers-Danlos Syndrome (EDS) — joint hypermobility pain, subluxation soreness, and chronic joint instability. Many EDS patients already take multiple oral medications and prefer topical options to reduce systemic load.

Mast Cell Activation Syndrome (MCAS) — for MCAS patients who experience musculoskeletal pain but need to be careful about oral medications and GI triggers, topical delivery bypasses the digestive system entirely.

Endometriosis-related pain — pelvic and lower abdominal muscle tension, lower back pain associated with endo flares, and post-surgical recovery.

POTS and dysautonomia — joint pain, muscle aches, and exercise recovery for patients managing autonomic dysfunction who want to minimize oral medication interactions.

Autoimmune joint pain — localized flares from rheumatoid arthritis, psoriatic arthritis, lupus, and other autoimmune conditions where adding another oral NSAID isn't ideal.

Neuropathy-adjacent pain — musculoskeletal pain that co-occurs with peripheral neuropathy, where oral NSAIDs may interact with existing medications.

Migraine and cluster headache tension — applied to the neck, temples, and base of the skull for the muscular tension component of migraine and cluster episodes.

Your provider will review your specific condition during the questionnaire process and determine if Ketro RX is appropriate for you.

Yes. TMJ is one of the most common use cases for Ketro RX. The gel is applied along the jawline, in front of the ear, and along the temple. Because it's topical, the ketorolac reaches the temporomandibular joint area directly without passing through your digestive system. Many people with TMJ take oral NSAIDs daily, which carries significant GI risk over time. Topical delivery avoids that entirely.

Ketro RX is commonly used for osteoarthritis pain in the knees, hands, wrists, and hips. For people who need daily NSAID relief but want to avoid the gastrointestinal risks of long-term oral use, a topical prescription-strength formulation allows targeted application directly to the affected joint. Peer-reviewed research shows topical NSAIDs achieve similar efficacy to oral NSAIDs with GI side effects comparable to placebo.

Topical NSAIDs penetrate through skin into the joint capsule and periarticular tissue. Research shows ketorolac reaches meaningful concentrations at depth when applied over the joint. It works best where the pain source is within ~4cm of the skin: knee, hand, elbow, ankle, jaw. For deeper joints like the hip, many customers still use it, but individual results vary more and pairing with oral medication or physical therapy may be needed.

Ketro RX was originally formulated for the Boston Red Sox training staff. Players used it on shoulders, knees, elbows, and other areas before and during games. It absorbs quickly, leaves no residue, and doesn't interfere with grip or mobility. It's used by athletes for acute injuries, post-training soreness, and chronic overuse conditions like tennis elbow and runner's knee.

It's a big jar. 100mL of prescription cream, and a small amount goes a long way. With regular use (a thin layer, 3-4 times daily as needed), one jar typically lasts up to 6 months.

Many people with fibromyalgia use Ketro RX for localized flare-ups and tender points. Fibro pain often shows up in specific areas (shoulders, neck, hips, lower back), and topical application lets you target those spots directly. Because it bypasses the digestive system, it doesn't add to the GI burden that many fibro patients already manage with other medications. Your provider will evaluate whether Ketro RX is appropriate based on your full health profile.

Ketro RX is commonly used by people with Ehlers-Danlos Syndrome and joint hypermobility for subluxation soreness, chronic joint pain, and the daily wear that comes with unstable joints. Many EDS patients prefer topical pain relief because they're already managing a complex medication regimen and want to reduce systemic load. Topical ketorolac delivers prescription-strength relief to the specific joint without oral side effects. Discuss with your provider during the questionnaire.

Because Ketro RX is applied topically and does not pass through the gastrointestinal system, it avoids many of the oral medication triggers that MCAS patients are concerned about. That said, everyone's mast cell triggers are different. We recommend discussing your specific MCAS profile with the provider during the questionnaire process. If your provider determines it's not appropriate for you, you pay nothing.

One of the advantages of topical delivery is minimal systemic absorption, which means fewer drug interactions compared to oral NSAIDs. This is especially relevant for people managing chronic conditions who are already on several medications. Your provider will review your current medications during the questionnaire and determine if Ketro RX is a safe addition to your regimen.

Yes. The provider review is included in your order. Never a separate charge.

Subscribe & Save starts at $110/mo on the 90-day plan (our best value) or $130/mo on the monthly plan. Cancel, pause, or adjust frequency anytime. No commitments.

Compounded per order by Precision Compounding Pharmacy, an FDA-registered, licensed US compounding facility. Every batch is made to order. Your gel is compounded specifically for you. Never mass-produced, never sitting on a shelf.